B Cells Loaded with Synthetic Particulate Antigens: A Versatile Platform To Generate Antigen-Specific Helper T Cells for Cell Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26650819.
- Also identified by DOI 10.1021/acs.nanolett.5b03801.
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Abstract
Adoptive cell therapy represents a promising approach for several chronic diseases. This study describes an innovative strategy for biofunctionalization of nanoparticles, allowing the generation of synthetic particulate antigens (SPAg). SPAg activate polyclonal B cells and vectorize noncognate proteins into their endosomes, generating highly efficient stimulators for ex vivo expansion of antigen-specific CD4+ T cells. This method also allows harnessing the ability of B cells to polarize CD4+ T cells into effectors or regulators.
Medical subject headings
- Cell- and Tissue-Based Therapy
- Immunotherapy, Adoptive
- Nanoparticles
- Vaccines, Synthetic