HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults.
Where this comes from
- Record sourced from PubMed, PMID 26655301.
- Also identified by DOI 10.1093/infdis/jiv592 and PMC identifier 4799671.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (hepatitis B e antigen status or HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8(+) T-cell response in HBV control, and potentially informs future therapeutic T-cell vaccine strategies.
Medical subject headings
- Coinfection
- HIV Infections
- HLA Antigens
- Hepatitis B
- Hepatitis B e Antigens