TRP channel mediated neuronal activation and ablation in freely behaving zebrafish.
basic_science · Level V
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- Record sourced from PubMed, PMID 26657556.
- Also identified by DOI 10.1038/nmeth.3691 and PMC identifier 4851460.
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Abstract
The zebrafish (Danio rerio) is a useful vertebrate model system in which to study neural circuits and behavior, but tools to modulate neurons in freely behaving animals are limited. As poikilotherms that live in water, zebrafish are amenable to thermal and pharmacological perturbations. We exploit these properties by using transient receptor potential (TRP) channels to activate or ablate specific neuronal populations using the chemical and thermal agonists of heterologously expressed TRPV1, TRPM8 and TRPA1.
Medical subject headings
- Gene Expression Regulation
- Sensory Receptor Cells
- Transient Receptor Potential Channels