Nanoscale optomechanical actuators for controlling mechanotransduction in living cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26657558.
- Also identified by DOI 10.1038/nmeth.3689 and PMC identifier 4732909.
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Abstract
To control receptor tension optically at the cell surface, we developed an approach involving optomechanical actuator nanoparticles that are controlled with near-infrared light. Illumination leads to particle collapse, delivering piconewton forces to specific cell surface receptors with high spatial and temporal resolution. We demonstrate optomechanical actuation by controlling integrin-based focal adhesion formation, cell protrusion and migration, and T cell receptor activation.
Medical subject headings
- Micro-Electrical-Mechanical Systems
- Nanoparticles
- Nanotechnology
- Receptors, Cell Surface