Rapid Multifocal Neurologic Decline in an Immunocompromised Patient.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 26658958.
- Also identified by DOI 10.1001/jamaneurol.2015.2658.
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Abstract
A man in his early 70s with a diagnosis of chronic lymphocytic leukemia and being treated with prednisone, fludarabine, cyclophosphamide, and rituximab presented with progressive multifocal neurologic decline. The patient died 2 months after the onset of this decline despite extensive clinical and laboratory investigation and a trial of methylprednisolone therapy. The approach to the immunosuppressed patient with progressive neurologic decline, neuropathologic findings, and final diagnosis are discussed.
Medical subject headings
- Antineoplastic Combined Chemotherapy Protocols
- Brain
- Immunocompromised Host
- Leukemia, Lymphocytic, Chronic, B-Cell
- Leukoencephalopathy, Progressive Multifocal