Supramolecular polyelectrolyte complex (SPEC): pH dependent phase transition and exploitation of its carrier properties.
basic_science · Level V
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- Record sourced from PubMed, PMID 26661046.
- Also identified by DOI 10.1039/c5sm02732b.
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Abstract
A supramolecular poly-electrolyte complex (SPEC) comprising poly-electrolyte acrylic acid with supramolecularly complexed guanidium is reported. This complex shows pH responsive phase transitions, which are described and characterized using microscopy, spectroscopy, density functional theory studies and Monte Carlo simulations. The phase behaviour of the SPEC is exploited by loading a dye like perylene and a drug, viz., doxorubicin, and their pH dependent controlled release is demonstrated, owing to the pH dependent phase change of the SPEC.