Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26663349.
- Also identified by DOI 10.1002/adma.201504288.
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Abstract
A novel fusogenic lipidic polyplex (FLPP) vector is designed to fuse with cell membranes, mimicking viropexis, and eject the polyplex into the cytosol, where the cationic polymer is subsequently oxidized by intracellular reactive oxygen species and converts to being negatively charged, efficiently releasing the DNA. The vector delivering suicide gene achieves significantly better inhibition of tumor growth than doxorubicin.
Medical subject headings
- Drug Carriers
- Gene Transfer Techniques
- Polymers
- Reactive Oxygen Species