Cell-to-Cell Transcript Variability: Seeing Signal in the Noise.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26687346.
- Also identified by DOI 10.1016/j.cell.2015.12.010 and PMC identifier 4926623.
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Abstract
How stochastic is gene expression in mammalian cells? Not very, according to Battich et al., who report that single-cell variability in cytoplasmic mRNAs is remarkably predictable given measurements of a cell's phenotypic state and microenvironment. The noise from transcriptional bursts is buffered by a hallmark of eukaryotes-the nucleus.
Medical subject headings
- Gene Expression Profiling