How Low Cholesterol Is Good for Anti-viral Immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26687349.
- Also identified by DOI 10.1016/j.cell.2015.12.004.
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Abstract
York et al. identify a role for decreased cholesterol biosynthesis in virally infected cells as a critical event in the induction of the anti-viral response. The mechanism involves enhanced signaling by STING in the ER membrane in response to the second messenger cGAMP, promoting increased transcription of type I interferons. The authors suggest that a "lipid code" is being sensed by STING to allow it to signal.
Medical subject headings
- Cholesterol
- Immunity, Innate
- Interferon-gamma
- Signal Transduction