Astrocytes Underlie Neuroinflammatory Memory Impairment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26687350.
- Also identified by DOI 10.1016/j.cell.2015.12.001 and PMC identifier 4786168.
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Abstract
Neuroinflammation is being increasingly recognized as a potential mediator of cognitive impairments in various neurological conditions. Habbas et al. demonstrate that the pro-inflammatory cytokine tumor necrosis factor alpha signals through astrocytes to alter synaptic transmission and impair cognition in a mouse model of multiple sclerosis.
Medical subject headings
- Astrocytes
- Dentate Gyrus
- Encephalomyelitis, Autoimmune, Experimental
- Memory
- Signal Transduction
- Tumor Necrosis Factor-alpha