Tough biodegradable mixed-macromer networks and hydrogels by photo-crosslinking in solution.
biomechanical · Level V
Where this comes from
- Record sourced from PubMed, PMID 26687979.
- Also identified by DOI 10.1016/j.actbio.2015.12.014.
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Abstract
The preparation of polymeric networks that are both tough and biodegradable remains a challenge. Here we show a very straightforward method to produce tough biodegradable networks from low molecular weight macromers for applications such as tissue engineering. Photo-crosslinking combinatorial mixtures of methacrylate-functionalized poly(1,3-trimethylene carbonate) (PTMC), poly(d,l-lactide) (PDLLA), poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) oligomers in propylene carbonate (PC) allowed the preparation of network films with excellent tensile characteristics and resistance to tearing. This method enabled the production of both very tough mixed-macromer elastomers as well as mixed-macromer hydrogels. A mixed-macromer hydrogel prepared from 33wt.% PTMC, 33wt.% PCL and 33wt.% PEG had a very high tearing energy of 0.81kJ/m(2), which is comparable to tearing energies determined for articular cartilage.
Medical subject headings
- Biocompatible Materials
- Hydrogels
- Photochemistry