A Lysosome-Targeting AIEgen for Autophagy Visualization.
basic_science · Level V
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- Record sourced from PubMed, PMID 26688031.
- Also identified by DOI 10.1002/adhm.201500674.
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Abstract
In this work, a morpholine-functionalized aggregation-induced emission luminogen (AIEgen), AIE-LysoY, is reported for lysosomal imaging and autophagy visualization. To attain outstanding imaging contrast, AIE-LysoY is equipped with excited state intramolecular proton transfer (ESIPT) characteristic. AIE-LysoY provides a new platform for lysosome visualization with good biocompatibility, large Stokes shift, superior signal-to-noise ratio, and high photostability.
Medical subject headings
- Autophagy
- Lysosomes
- Molecular Probes
- Morpholines