A General Strategy for Facile Synthesis and In Situ Screening of Self-Assembled Polymer-Peptide Nanomaterials.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26698326.
- Also identified by DOI 10.1002/adma.201504564.
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Abstract
A universal strategy for efficient, mild, and purification-free synthesis and in situ screening of functional polymer-peptide nanomaterials is described. More than 1000 polymer-peptide conjugates (PPCs) with various chemical structures, compositions, and therapeutic efficacy are created. According to this strategy, the structure-function relationship of the PPCs is revealed, and the antitumor efficacies of the top performing PPCs are evaluated in vivo.
Medical subject headings
- Nanoparticles
- Nanotechnology
- Peptides
- Polymers