Design of Major Randomized Trials: Part 3 of a 4-Part Series on Statistics for Clinical Trials.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26700838.
- Also identified by DOI 10.1016/j.jacc.2015.10.036.
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Abstract
This paper provides practical guidance on the fundamentals of design for major randomized controlled trials. Topics covered include the choice of patients, choice of treatment and control groups, choice of primary and secondary endpoints, methods of randomization, appropriate use of blinding, and determination of trial size. Insights are made with reference to contemporary major trials in cardiology.
Medical subject headings
- Cardiovascular Diseases
- Patient Selection
- Randomized Controlled Trials as Topic