Histone deacetylase activity and recurrent bacterial bronchitis in severe eosinophilic asthma.
Where this comes from
- Record sourced from PubMed, PMID 26715426.
- Also identified by DOI 10.1111/all.12831.
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Abstract
An increase in P13 Kinase activity and an associated reduction in histone deacetylase activity may contribute to both relative steroid insensitivity in patients with severe eosinophilic asthma and impaired macrophage scavenger function and susceptibility to recurrent infective bronchitis that may, in turn, contribute to further steroid insensitivity.
Medical subject headings
- Asthma
- Bacterial Infections
- Bronchitis