Challenging Issues in Clinical Trial Design: Part 4 of a 4-Part Series on Statistics for Clinical Trials.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26718676.
- Also identified by DOI 10.1016/j.jacc.2015.10.051.
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Abstract
As a sequel to last week's paper on the fundamentals of clinical trial design, this paper tackles related controversial issues: noninferiority trials, the value of factorial designs, the importance and challenges of strategy trials, Data Monitoring Committees (including when to stop a trial early), and the role of adaptive designs. All topics are illustrated by relevant examples from cardiology trials.
Medical subject headings
- Cardiology
- Clinical Trials Data Monitoring Committees
- Clinical Trials as Topic
- Guidelines as Topic