Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26727632.
- Also identified by DOI 10.1021/acs.nanolett.5b02428 and PMC identifier 5278877.
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Abstract
Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII and mRNA-encoding erythropoietin (EPO) in mice. Importantly, these nanoparticles were well-tolerated at their effective dose based on analysis of tissue histology, systemic cytokine levels, and liver enzyme chemistry. The polymer brush nanoparticles reported here are promising for therapeutic applications.
Medical subject headings
- Gene Transfer Techniques
- Genetic Therapy
- Nanoparticles
- RNA, Messenger