Alzheimer's disease: the amyloid hypothesis on trial.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26729836.
- Also identified by DOI 10.1192/bjp.bp.115.167569.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypothesis.
Medical subject headings
- Alzheimer Disease
- Amyloid beta-Peptides
- Brain