Data gaps limit the translational potential of preclinical research.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26738793.
- Also identified by DOI 10.1126/scitranslmed.aac9888.
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Abstract
The absence of mouse pharmacokinetic reference data hinders translation. An analysis of recent literature highlights a systematic lack of discussion regarding rationale for the selection of dosing paradigms in preclinical studies, and in particular for neuroscience studies in which the lack of brain penetration can limit target-organ exposure. We propose solutions to improve study design.
Medical subject headings
- Drug Evaluation, Preclinical
- Statistics as Topic
- Translational Research, Biomedical