Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26743228.
- Also identified by DOI 10.1002/adma.201505524.
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Abstract
A stability-difference-selective bond-breakage strategy for the fabrication of largepore-sized hollow mesoporous organosilica nanoparticles (HMONs) is successfully developed. Moreover, surfacefunctionalized HMONs are successfully constructed to simultaneously deliver P-gp modulator siRNA and anticancer drug doxorubicin to reverse the multidrug resistance of cancer cells.
Medical subject headings
- Drug Carriers
- Gene Transfer Techniques
- Silicon Dioxide