Investigating a new drug delivery nano composite membrane system based on PVA/PCL and PVA/HA(PEG) for the controlled release of biopharmaceuticals for bone infections.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26747917.
- Also identified by DOI 10.1016/S0020-1383(15)30053-X.
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Abstract
The capability for sustained and gradual release of pharmaceuticals is a major requirement in the development of a guided antimicrobial bacterial control system for clinical applications. In this study, PVA gels with varying constituents that were manufactured via a refreeze/thawing route, were found to have excellent potential for antimicrobial delivery for bone infections. Cefuroxime Sodium with poly(ethylene glycol) was incorporated into 2 delivery systems poly(e-caprolactone) (PCL) and hydroxyapatite (HA), by a modified emulsion process. Our results indicate that the Cefuroxime Sodium released from poly(e-caprolactone) in PVA was tailored to a sustained release over more than 45 days, while the release from hydroxyapatite PVA reach burst maximum after 20 days. These PVA hydrogel-systems were also capable of controlled and sustained release of other biopharmaceuticals.
Medical subject headings
- Biocompatible Materials
- Biphenyl Compounds
- Delayed-Action Preparations
- Drug Delivery Systems
- Hydrogel, Polyethylene Glycol Dimethacrylate
- Osteomyelitis