Lifting the Mist on Gastric Stem Cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26748749.
- Also identified by DOI 10.1016/j.stem.2015.12.008.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In a recent issue of Cancer Cell, Hayakawa et al. (2015) demonstrate that Mist1(+) gastric stem cells are supported by a specialized niche composed of Cxcl12(+) endothelium and Wnt5a-producing Cxcr4(+) innate lymphoid cells. In diffuse-type gastric cancer this perivascular stem cell niche is expanded and can be exploited for cancer therapy.
Medical subject headings
- Basic Helix-Loop-Helix Proteins
- Epithelial Cells
- Gastric Mucosa
- Neoplastic Stem Cells
- Stem Cell Niche
- Stomach Neoplasms
- Tumor Microenvironment