Engineering Stem Cell Organoids.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26748754.
- Also identified by DOI 10.1016/j.stem.2015.12.005 and PMC identifier 4728053.
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Abstract
Organoid systems leverage the self-organizing properties of stem cells to create diverse multi-cellular tissue proxies. Most organoid models only represent single or partial components of a tissue, and it is often difficult to control the cell type, organization, and cell-cell/cell-matrix interactions within these systems. Herein, we discuss basic approaches to generate stem cell-based organoids, their advantages and limitations, and how bioengineering strategies can be used to steer the cell composition and their 3D organization within organoids to further enhance their utility in research and therapies.
Medical subject headings
- Cell Culture Techniques
- Organoids
- Stem Cells