Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 26758262.
- Also identified by DOI 10.1136/bmjopen-2015-009499 and PMC identifier 4716257.
- Licence recorded as CC BY-NC.
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Abstract
The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, in European populations. This study aims to assess the genetic association of the variant rs75932628-T with PD and leucoaraiosis (LA) in a Han Chinese population. This population-based study was conducted in China by Xiamen University and its affiliated hospital. 308 patients with LA, 342 patients with PD and 198 healthy blood donors were recruited from the First Affiliated Hospital of Xiamen University. Genotyping was performed by molecular beacon real-time PCR and Sanger sequencing. None of our participants carried the rs75932628-T mutation. Our results corroborate and extend previous findings, concluding that the variant rs75932628-T (p.R47H) in TREM2 is not a risk factor for LA or PD in the Han Chinese population.
Medical subject headings
- Alzheimer Disease
- Asian People
- Genotype
- Membrane Glycoproteins
- Mutation
- Parkinson Disease
- Polymorphism, Genetic
- Receptors, Immunologic