Fibroblast growth factor receptor 4: the missing link between chronic kidney disease and FGF23-induced left ventricular hypertrophy?
Where this comes from
- Record sourced from PubMed, PMID 26759036.
- Also identified by DOI 10.1016/j.kint.2015.11.012.
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Abstract
Serum phosphorus and the regulatory hormone fibroblast growth factor 23 have been strongly linked to cardiovascular morbidity and mortality in patients with chronic kidney disease. A recent study identified fibroblast growth factor receptor 4 as the primary receptor mediating the effect of fibroblast growth factor 23 on left ventricular hypertrophy, providing new mechanistic insights and a potential therapeutic target to reduce cardiovascular morbidity in chronic kidney disease.
Medical subject headings
- Fibroblast Growth Factor 3
- Hypertrophy, Left Ventricular
- Kidney Failure, Chronic
- Receptor, Fibroblast Growth Factor, Type 4