Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants.
Where this comes from
- Record sourced from PubMed, PMID 26765328.
- Also identified by DOI 10.1371/journal.pone.0146642 and PMC identifier 4713093.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different mechanisms to optimize control measures. We conducted a prospective cohort study of index TB patients and their household contacts in Lima, Peru to identify risk factors associated with acquired and transmitted resistance, respectively. Patients with higher socioeconomic status (SES) had a 3-fold increased risk of transmitted resistance compared to those with lower SES when acquired resistance served as the baseline. Quality of housing mediated most of the impact of SES.
Medical subject headings
- Tuberculosis, Multidrug-Resistant
- Tuberculosis, Pulmonary