An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26765567.
- Also identified by DOI 10.7554/eLife.10856 and PMC identifier 4775223.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.
Medical subject headings
- Autophagy
- Fungal Proteins
- Host-Pathogen Interactions
- Phytophthora infestans
- Plant Diseases
- Plant Proteins
- Solanum tuberosum