Can Insulin Production Suppress β Cell Growth?
Level V
Where this comes from
- Record sourced from PubMed, PMID 26771111.
- Also identified by DOI 10.1016/j.cmet.2015.12.016.
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Abstract
While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.
Medical subject headings
- Insulin
- Insulin-Secreting Cells