Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1.
Level V
Where this comes from
- Record sourced from PubMed, PMID 26771113.
- Also identified by DOI 10.1016/j.cmet.2015.12.011.
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Abstract
How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation.
Medical subject headings
- Diabetes Mellitus, Type 2
- Insulin-Secreting Cells