A New aDENNDum to Genetics of Childhood Asthma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26771480.
- Also identified by DOI 10.1016/j.cell.2015.12.045.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a molecular basis for how DENND1B contributes to asthma pathogenesis.
Medical subject headings
- Asthma
- Death Domain Receptor Signaling Adaptor Proteins
- Guanine Nucleotide Exchange Factors
- Receptors, Antigen, T-Cell
- Signal Transduction
- Th2 Cells