Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26771694.
- Also identified by DOI 10.1021/acs.nanolett.5b03854.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A physiologically based pharmacokinetic model was developed for accurately characterizing and predicting the in vivo fate of long-circulating inorganic nanoparticles (NPs). This model is built based on direct visualization of NP disposition details at the organ and cellular level. It was validated with multiple data sets, indicating robust inter-route and interspecies predictive capability. We suggest that the biodistribution of long-circulating inorganic NPs is determined by the uptake and release of NPs by phagocytic cells in target organs.
Medical subject headings
- Inorganic Chemicals
- Nanoparticles
- Pharmacokinetics
- Quantum Dots