Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 26777972.
- Also identified by DOI 10.1016/j.athoracsur.2015.09.023.
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Abstract
Hypertrophic osteoarthrpathy (HO) is a rare paraneoplasic syndrome associated with non-small cell lung cancer (NSCLC). The pathophysiology of HO is unknown but was recently related to enhanced levels of urine prostaglandin E2 (PGE2). Here, we report the case of a patient that presented HO in association with a resectable left upper lobe NSCLC. Following surgery and adjuvant chemotherapy, HO resolved and did not recur with development of a brain metastasis 1 year later. Interestingly, tumor cyclooxygenase-2, an enzyme responsible the synthesis of PGE2, was expressed in the primary tumor but not in the resected metastasis.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Cyclooxygenase 2
- Lung Neoplasms
- Osteoarthropathy, Secondary Hypertrophic
- Paraneoplastic Syndromes