Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure.
Where this comes from
- Record sourced from PubMed, PMID 26778095.
- Also identified by DOI 10.1016/j.jpeds.2015.11.076.
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Abstract
Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.
Medical subject headings
- Costello Syndrome
- Energy Metabolism
- Failure to Thrive
- Rest