Human surrogate models of neuropathic pain: validity and limitations.
Level V
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- Record sourced from PubMed, PMID 26785155.
- Also identified by DOI 10.1097/j.pain.0000000000000460.
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Abstract
Human surrogate models of neuropathic pain in healthy subjects are used to study symptoms, signs, and the hypothesized underlying mechanisms. Although different models are available, different spontaneous and evoked symptoms and signs are inducible; 2 key questions need to be answered: are human surrogate models conceptually valid, ie, do they share the sensory phenotype of neuropathic pain states, and are they sufficiently reliable to allow consistent translational research?
Medical subject headings
- Models, Theoretical
- Neuralgia