Activation of TRAIL-DR5 pathway promotes sensorineural degeneration in the inner ear.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26791792.
- Also identified by DOI 10.1111/acel.12437 and PMC identifier 4783338.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF-α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF-related apoptosis-inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5-blocking antibodies.
Medical subject headings
- Hair Cells, Auditory, Inner
- Hearing Loss, Sensorineural
- Receptors, TNF-Related Apoptosis-Inducing Ligand
- TNF-Related Apoptosis-Inducing Ligand