Central regions of keloids are severely ischaemic.
Where this comes from
- Record sourced from PubMed, PMID 26794626.
- Also identified by DOI 10.1016/j.bjps.2015.11.006.
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Abstract
We classified scars as keloids, hypertrophic scars and mature scars, and then examined the scars for differences in central and marginal vascularization. We found significant differences in localized hypoxia-induced factor-1α (HIF-1α) expression and vascular density in keloids, but no localized differences in hypertrophic or mature scars. The central areas of keloids exhibited higher HIF-1α expression and lower vascular density than marginal areas, suggesting that the former are severely ischaemic.
Medical subject headings
- Cicatrix, Hypertrophic
- Ischemia
- Keloid
- Skin