Induction of Calcium Influx in Cortical Neural Networks by Nanomagnetic Forces.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26805612.
- Also identified by DOI 10.1021/acsnano.5b07118.
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Abstract
Nanomagnetic force stimulation with ferromagnetic nanoparticles was found to trigger calcium influx in cortical neural networks without observable cytotoxicity. Stimulated neural networks showed an average of 20% increment in calcium fluorescence signals and a heightened frequency in calcium spiking. These effects were also confined spatially to areas with engineered high magnetic field gradients. Furthermore, blockage of N-type calcium channels inhibited the stimulatory effects of the nanomagnetic forces, suggesting the role of mechano-sensitive ion channels in mediating calcium influx.
Medical subject headings
- Calcium Signaling
- Cerebral Cortex
- Magnetite Nanoparticles
- Nerve Net
- Neurons