Click-Crosslinked Injectable Gelatin Hydrogels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26806652.
- Also identified by DOI 10.1002/adhm.201500757 and PMC identifier 4849477.
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Abstract
Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and biodegradation when injected in vivo.
Medical subject headings
- Click Chemistry
- Cross-Linking Reagents
- Gelatin
- Hydrogels