Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26808201.
- Also identified by DOI 10.1371/journal.pone.0147211 and PMC identifier 4726573.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Despite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal. Therapy with tumor-selective viruses is emerging as a treatment option for this devastating disease. In this study we characterize the anti-glioma effect of VCN-01, an improved hyaluronidase-armed pRB-pathway-selective oncolytic adenovirus that has proven safe and effective in the treatment of several solid tumors. VCN-01 displayed a significant cytotoxic effect on glioma cells in vitro. In vivo, in two different orthotopic glioma models, a single intra-tumoral administration of VCN-01 increased overall survival significantly and led to long-term survivors free of disease.
Medical subject headings
- Adenoviruses, Human
- Brain Neoplasms
- Glioma
- Oncolytic Virotherapy
- Oncolytic Viruses