Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26812545.
- Also identified by DOI 10.7554/eLife.11911 and PMC identifier 4764553.
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Abstract
Human cytomegalovirus (hCMV) immediate early 1 (IE1) protein associates with condensed chromatin of the host cell during mitosis. We have determined the structure of the chromatin-tethering domain (CTD) of IE1 bound to the nucleosome core particle, and discovered that IE1-CTD specifically interacts with the H2A-H2B acidic patch and impairs the compaction of higher-order chromatin structure. Our results suggest that IE1 loosens up the folding of host chromatin during hCMV infections.
Medical subject headings
- Chromatin
- Cytomegalovirus
- Host-Pathogen Interactions
- Immediate-Early Proteins
- Nucleosomes