Particles for Local Delivery of Proteins Using Intra-Articular Route.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26833828.
- Also identified by DOI 10.1002/adhm.201500797 and PMC identifier 4852977.
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Abstract
Designing a vehicle for local delivery of proteins using intra-articular route is an attractive option to minimize the adverse effects associated with systemic exposure and to maximize the efficacy. Slowly dissolving silylated microparticles are designed with specific size and shape that are capable of extending the retention time of a model protein (bovine serum albumin) in the murine knee joint. No cytotoxicity is observed for the reconstituted formulation when tested against synovial fibroblasts and RAW 264.7 macrophages.
Medical subject headings
- Serum Albumin, Bovine