Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26840751.
- Also identified by DOI 10.1002/adma.201505336.
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Abstract
A novel photogelling mechanism by the phototriggered-imine-crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o-nitrobenzene, a photogenerated aldehyde group, can quickly photo-crosslink with amino-bearing polymers or proteins. Once the in situ photogelling on a wound occurs, the PIC gelling process can well integrate a hydrogel with surrounding tissue by covalent bonding, thus making it a powerful tool for tissue engineering and regenerative medicine.
Medical subject headings
- Biocompatible Materials
- Imines
- Ultraviolet Rays