Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26844941.
- Also identified by DOI 10.1002/adhm.201500792 and PMC identifier 4828275.
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Abstract
A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N-isopropylacrylamide) microfibers. The capillary-like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.
Medical subject headings
- Gelatin
- Hydrogels
- Microvessels
- Temperature