Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26849297.
- Also identified by DOI 10.1016/j.stem.2016.01.004 and PMC identifier 7240163.
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Abstract
The mechanisms by which imprinted loci control activity of hematopoietic stem cells (HSCs) are not known. In this issue of Cell Stem Cell, Qian et al. (2016) demonstrate that non-coding RNAs expressed by the maternal-imprinted locus Dlk1-Gtl2 maintain HSC self-renewal through the inhibition of PI3K-mTOR signaling, mitochondrial biogenesis, and metabolic activity.
Medical subject headings
- Hematopoietic Stem Cells
- Phosphatidylinositol 3-Kinases