Compacting Chromatin to Ensure Muscle Satellite Cell Quiescence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26849299.
- Also identified by DOI 10.1016/j.stem.2016.01.009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Satellite cells comprise a pool of quiescent stem cells that repair muscle damage, but the mechanisms enforcing their quiescence are poorly defined. In this issue of Cell Stem Cell, Boonsanay et al. (2016) show that the histone methyltransferase Suv4-20H1 maintains satellite cell quiescence by promoting a heterochromatic state through transcriptional repression of the myogenic master regulator MyoD.
Medical subject headings
- Chromatin
- Satellite Cells, Skeletal Muscle