Sensory and optogenetically driven single-vessel fMRI.
basic_science · Level V
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- Record sourced from PubMed, PMID 26855362.
- Also identified by DOI 10.1038/nmeth.3765 and PMC identifier 6298439.
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Abstract
Magnetic resonance imaging (MRI) sensitivity approaches vessel specificity. We developed a single-vessel functional MRI (fMRI) method to image the contribution of vascular components to blood oxygenation level-dependent (BOLD) and cerebral blood volume (CBV) fMRI signal. We mapped individual vessels penetrating the rat somatosensory cortex with 100-ms temporal resolution by MRI with sensory or optogenetic stimulation. The BOLD signal originated primarily from venules, and the CBV signal from arterioles. The single-vessel fMRI method and its combination with optogenetics provide a platform for mapping the hemodynamic signal through the neurovascular network with specificity at the level of individual arterioles and venules.
Medical subject headings
- Brain
- Brain Mapping
- Magnetic Resonance Imaging
- Optogenetics
- Oxygen
- Somatosensory Cortex