Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26865105.
- Also identified by DOI 10.1002/adhm.201500956 and PMC identifier 4836958.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites contract synchronously, facilitating the use of this tissue-engineering platform to study structure-function relationships in the heart.
Medical subject headings
- Heart
- Tissue Engineering