A Mechanism for Somatic Brain Mosaicism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26871622.
- Also identified by DOI 10.1016/j.cell.2016.01.048.
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Abstract
Double-strand break repair is required for neural development, and brain cells contain somatic genomic variations. Now, Wei et al. demonstrate that neural stem and progenitor cells undergo very frequent DNA breaks in a very restricted set of genes involved in neural cell adhesion and synapse function.
Medical subject headings
- DNA Breaks
- Neural Stem Cells