Pluripotency without Proliferation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26871623.
- Also identified by DOI 10.1016/j.cell.2016.01.050.
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Abstract
Mouse embryonic stem cells (mESCs) are capable of unlimited proliferation without losing pluripotency. Scognamiglio et al. now reveal that Myc depletion shifts mESCs into a dormant state reminiscent of embryonic diapause in which pluripotency remains fully preserved, thus decoupling pluripotency from proliferative programs.
Medical subject headings
- Embryonic Stem Cells
- Genes, myc
- Proto-Oncogene Proteins c-myc