Let It Go and Open Up, an Ensemble of Ion Channel Active States.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26871624.
- Also identified by DOI 10.1016/j.cell.2016.01.037.
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Abstract
Ligand binding usually moves the target protein from an ensemble of inactive states to a well-defined active conformation. Matthies et al. flip this scheme around, finding that, for the magnesium channel CorA, loss of ligand binding induces an ensemble of conformations that turn the channel on.
Medical subject headings
- Bacterial Proteins
- Cation Transport Proteins
- Magnesium
- Thermotoga maritima